Evaluating Gene Therapy Distribution & Delivery to the CNS
Time: 4:30 pm
day: Day One
Details:
- Various routes are used for AAV delivery to the CNS, including intravascular, intraventricular, intracisternal magna and intrathecal
- Using I-124-labeled AAV capsids and positron emission tomography, it is possible to accurately quantify where the vectors immediately distribute
- Despite the route and the capsid, a significant proportion of CNS administered AAV vector is delivered to organs outside of the nervous system
